Description

Ipratropium Bromide is a quaternary ammonium anticholinergic agent, widely recognized for its bronchodilator properties. This high-purity active pharmaceutical ingredient (API) is critical for the formulation of reliable and effective respiratory medications. It is primarily utilized by pharmaceutical manufacturers in the development of inhalation therapies for chronic obstructive pulmonary disease (COPD) and asthma management.

Application

• Pharmaceutical API: Primary active ingredient in metered-dose inhalers (MDIs), dry powder inhalers (DPIs), and nebulizer solutions for the treatment of chronic obstructive pulmonary disease (COPD) and bronchial asthma.
• Combination Therapies: Used in fixed-dose combination products with β-2 agonists (e.g., Salbutamol, Fenoterol) for enhanced bronchodilation and improved patient compliance.
• Respiratory Research: Serves as a reference standard and key reagent in preclinical and clinical research focused on cholinergic pathways and pulmonary pharmacology.
• Veterinary Medicine: Applied in veterinary pharmaceuticals for managing bronchoconstriction in animals.
• Analytical Standard: Employed as a high-purity certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.

Basic Information

Product Name	Ipratropium Bromide
CAS No.	22254-24-6
Molecular Formula	C20H30BrNO3
Molecular Weight	412.37 g/mol
Synonyms	8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, (1R,3r,5S)-; Atrovent; Ipratropium; Sch 1000; (1R,5S)-3-[(2S)-3-Hydroxy-2-phenylpropanoyl]oxy-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane bromide; Ipratropii Bromidum; BA 253 BR-L
EINECS	244-876-5

Quality Control

Our Ipratropium Bromide is manufactured under strict quality management systems. Each batch is tested to ensure compliance with major pharmacopoeial standards such as USP, EP, and BP. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing results for identity, purity, assay, and specified impurities. We support regulatory submissions with full traceability and stability data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.