Description

Tramadol Hydrochloride CAS NO 22204-88-2 is a synthetic opioid analgesic of the aminocyclohexanol group. It is a centrally acting pain reliever that binds to μ-opioid receptors and inhibits the reuptake of norepinephrine and serotonin. This product is essential for the formulation of effective pain management medications. It is primarily required by pharmaceutical manufacturers and research institutions developing analgesic drugs for moderate to moderately severe pain.

Application

• Active Pharmaceutical Ingredient (API) in the manufacture of prescription analgesic tablets and capsules.
• Formulation component for controlled-release and immediate-release oral solid dosage forms.
• Used in clinical research for studying pain pathways and analgesic efficacy.
• Key intermediate in the synthesis of more complex pharmaceutical compounds.
• Reference standard in analytical laboratories for quality control and method validation.
• Essential material for compounding pharmacies preparing specialized pain management formulations.

Basic Information

Product Name	Tramadol Hydrochloride
CAS No.	22204-88-2
Molecular Formula	C16H25NO2 • HCl
Molecular Weight	299.84 g/mol
Synonyms	(1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride; Tramadol HCl; Tramal; Ultram; CG 315; Zydol; Tradol; Contramal; Crispin; Ralivia; Ryzolt; Rybix ODT
EINECS	244-857-1

Quality Control

Our Tramadol Hydrochloride is manufactured under strict quality management systems. It is tested to meet or exceed relevant pharmacopeial standards, including USP and EP monographs. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles to ensure consistency and regulatory compliance for pharmaceutical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.5% (on anhydrous basis)
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.1% Total impurities: ≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	+28° to +32° (c = 1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.