Description

Ethyl (5-Bromothien-2-Yl)Glyoxylate is a high-value brominated heterocyclic building block, specifically an ester derivative of glyoxylic acid. This compound is critical for its role as a versatile synthon in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of thiophene-containing drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Used in developing novel herbicides and fungicides where the bromothiophene moiety imparts specific biological activity.
• Material Science: Serves as a building block for organic semiconductors, conductive polymers, and non-linear optical (NLO) materials.
• Chemical Synthesis: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) and as a substrate for further functionalization of the glyoxylate group.
• Ligand and Catalyst Development: Useful for creating novel chelating ligands for transition metal catalysis.

Basic Information

Product Name	Ethyl (5-Bromothien-2-Yl)Glyoxylate
CAS No.	22098-10-8
Molecular Formula	C8H7BrO3S
Molecular Weight	263.11 g/mol
Synonyms	Ethyl 5-bromothiophene-2-glyoxylate; 5-Bromo-2-thienylglyoxylic Acid Ethyl Ester; Ethyl (5-bromo-2-thienyl)oxoacetate; (5-Bromothiophen-2-yl)-oxo-acetic acid ethyl ester; 2-Thiopheneglyoxylic acid, 5-bromo-, ethyl ester; Ethyl α-oxo-5-bromothiophene-2-acetate; Glyoxylic acid, (5-bromo-2-thienyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl (5-Bromothien-2-Yl)Glyoxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of research and development as well as cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.