Description

[6As,(+)]-5,6,6A,7-Tetrahydro-1,2,9,10-Tetramethoxy-4H-Dibenzo[De,G]Quinoline CAS NO 21848-62-4 is a high-purity, chiral alkaloid derivative belonging to the protoberberine class, characterized by its complex tetracyclic structure. This compound is of significant value in advanced pharmaceutical research and development, particularly as a critical chiral intermediate or reference standard. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of novel bioactive molecules, especially within the fields of neurology and oncology.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block for the synthesis of complex alkaloids and potential drug candidates.
• Biochemical Research: Used as a reference standard or probe in studying enzyme inhibition, receptor binding, and other biological mechanisms.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions due to its defined stereochemistry at the 6a position.
• Natural Product Analog Development: Acts as a core scaffold for creating analogs of natural protoberberine alkaloids to explore new therapeutic properties.
• Academic Research: Utilized in universities and research labs for methodological studies in organic synthesis and medicinal chemistry.

Basic Information

Product Name	[6As,(+)]-5,6,6A,7-Tetrahydro-1,2,9,10-Tetramethoxy-4H-Dibenzo[De,G]Quinoline
CAS No.	21848-62-4
Molecular Formula	C21H25NO4
Molecular Weight	355.43 g/mol
Synonyms	(+)-Canadine; (6aS)-5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-4H-dibenzo[de,g]quinoline; (6aS)-Tetrahydroberberine; L-Canadine; (6aS)-Canadine; (S)-Canadine; NSC 158923; Berberine, tetrahydro-, (S)-
EINECS	Contact for details

Quality Control

Our [6As,(+)]-5,6,6A,7-Tetrahydro-1,2,9,10-Tetramethoxy-4H-Dibenzo[De,G]Quinoline is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.