Description

(+)-Phyllodulcin CAS NO 21499-23-0 is a naturally occurring dihydroisocoumarin derivative and a potent, non-caloric sweetener. It matters as a high-intensity sweetening agent with a clean taste profile and potential health-conscious applications, being significantly sweeter than sucrose. This compound is needed by manufacturers in the food & beverage, nutraceutical, and pharmaceutical industries seeking natural-origin, sugar-free alternatives for product formulation.

Application

• Food & Beverage Additive: As a high-potency sweetener in sugar-free or reduced-calorie products, beverages, and confectionery.
• Nutraceutical & Dietary Supplements: Used in vitamin gummies, protein powders, and health supplements requiring palatability without added sugars.
• Pharmaceutical Formulations: Employed as a taste-masking agent in syrups, chewable tablets, and oral suspensions to improve patient compliance.
• Flavor & Fragrance Industry: Serves as a key intermediate or reference standard in the synthesis and analysis of sweet-tasting compounds.
• Research & Development: Utilized as a standard in analytical chemistry and biological studies related to taste receptors (T1R2/T1R3) and sweet perception.
• Natural Product Extraction & Standardization: Acts as a marker compound for the quality control of plant extracts, particularly from Hydrangea macrophylla and related species.

Basic Information

Item	Detail
Product Name	(+)-Phyllodulcin
CAS No.	21499-23-0
Molecular Formula	C16H14O5
Molecular Weight	286.28 g/mol
Synonyms	Phyllodulcin; (3R)-3-(3,4-Dihydroxyphenyl)-3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one; 8-Hydroxy-3-(3,4-dihydroxyphenyl)-3,4-dihydroisocoumarin; Hydrangeol; NSC 407303; Natural Sweetener 8-Hydroxy-3-(3,4-dihydroxyphenyl)isochroman-1-one; Sweet hydrangea principle
EINECS	Contact for details

Quality Control

Our (+)-Phyllodulcin is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for food and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and heavy metals is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.