Description

[R,(-)]-6-[(1R)-1,2,3,4-Tetrahydro-6,7-Dimethoxy-2-Methylisoquinolin-1-Yl]Furo[3,4-E]-1,3-Benzodioxol-8(6H)-One is a complex, chiral organic compound belonging to the isoquinoline alkaloid family. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the synthesis of bioactive molecules targeting neurological pathways. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the production of advanced drug candidates and reference standards.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of potential central nervous system (CNS) active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard or probe compound in pharmacological studies, especially those investigating receptor binding and enzyme inhibition.
• Process Chemistry: Serves as a critical intermediate in scale-up and optimization studies for new chemical entities (NCEs).
• Asymmetric Synthesis: Utilized in the development of stereoselective synthetic routes due to its defined chiral centers.
• Academic Research: Employed in university and institutional labs for methodological development in organic and medicinal chemistry.
• Custom Synthesis: Starting material for the preparation of more complex, proprietary analogs for drug discovery programs.

Basic Information

Product Name	[R,(-)]-6-[(1R)-1,2,3,4-Tetrahydro-6,7-Dimethoxy-2-Methylisoquinolin-1-Yl]Furo[3,4-E]-1,3-Benzodioxol-8(6H)-One
CAS No.	21414-43-7
Molecular Formula	C₂₃H₂₅NO₆
Molecular Weight	411.45 g/mol
Synonyms	(-)-Galanthamine N-Oxide; Galanthamine N-Oxide; (1R,12R,13S)-13-Methyl-5,6,12,13,14,15-hexahydro-4H-8,10-dimethoxy-1,12-epoxy[1,3]dioxolo[4,5-h]pyrrolo[3,2,1-de]phenanthridin-4-one; 1,12-Epoxy-13-methyl-5,6,12,13,14,15-hexahydro-4H-8,10-dimethoxy[1,3]dioxolo[4,5-h]pyrrolo[3,2,1-de]phenanthridin-4-one; Galanthaminone N-Oxide; Lycoramine N-Oxide
EINECS	Contact for details

Quality Control

Our [R,(-)]-6-[(1R)-1,2,3,4-Tetrahydro-6,7-Dimethoxy-2-Methylisoquinolin-1-Yl]Furo[3,4-E]-1,3-Benzodioxol-8(6H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) documenting identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.