Description

L-Alanine-2-D1 is a stable isotope-labeled analog of the essential amino acid L-alanine, specifically deuterated at the 2-position. This precise labeling is critical for applications requiring high specificity and minimal background interference in analytical techniques. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for advanced metabolic studies, internal standards, and tracer methodologies.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a crucial quantitative reference in LC-MS and GC-MS analysis of amino acids and related metabolites.
• Metabolic Pathway Tracing: Used in NMR spectroscopy and MS-based studies to elucidate biochemical pathways and flux analysis.
• Pharmaceutical Research & Development: Employed in the synthesis of deuterated drug candidates for pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies.
• Proteomics and Biomarker Discovery: Facilitates accurate relative and absolute quantification of proteins and peptides in complex biological samples.
• Nutritional Science Research: Applied in studies investigating protein metabolism, turnover, and amino acid utilization.
• Quality Control Reference Material: Acts as a high-purity standard for calibrating analytical instruments and validating methods in quality control laboratories.

Basic Information

Item	Detail
Product Name	L-Alanine-2-D1
CAS No.	21386-65-2
Molecular Formula	C₃H₆DNO₂
Molecular Weight	90.10 g/mol
Synonyms	(2S)-2-Amino(2-²H)propanoic acid; (S)-Alanine-2-d; L-α-Alanine-2-d; Deuterated L-alanine; L-Alanine-d1; Alanine-2-d1; (S)-2-Aminopropionic-2-d acid; 2-Deutero-L-alanine
EINECS	Contact for details

Quality Control

Our L-Alanine-2-D1 is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including NMR and Mass Spectrometry, to confirm isotopic enrichment, chemical purity, and chiral integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key specifications. We support compliance with relevant regulatory frameworks for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (²H NMR/MS)	≥ 98 atom % D
Optical Rotation	[α]²⁰D: +13.5° to +15.5° (c=1 in H₂O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.