Description

Methyl (Triphenylphosphoranylidene)Acetate is a high-value Wittig reagent, specifically a stabilized ylide, essential for the synthesis of α,β-unsaturated esters via the Horner-Wadsworth-Emmons reaction. Its primary value lies in providing a reliable and often stereoselective route to generate alkene products with predictable (E)-selectivity under mild conditions. This compound is a critical building block for researchers and process chemists in pharmaceutical development, agrochemical synthesis, and advanced material science, where precise carbon-carbon double bond formation is required.

Application

• Pharmaceutical Intermediates: Key reagent for synthesizing drug candidates containing α,β-unsaturated ester moieties, including protease inhibitors and other bioactive molecules.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides that require specific alkene frameworks for optimal activity.
• Fine Chemical Manufacturing: Employed in the multistep synthesis of complex natural products, flavors, and fragrances.
• Material Science Research: Facilitates the creation of novel monomers and polymers with tailored properties through controlled olefination reactions.
• Academic & R&D Laboratories: A staple reagent for methodological development and exploratory organic synthesis in university and industrial research settings.
• Specialty Chemical Production: Integral to manufacturing customized chemical entities for electronics and performance chemicals.

Basic Information

Product Name	Methyl (Triphenylphosphoranylidene)Acetate
CAS No.	21204-67-1
Molecular Formula	C21H19O2P
Molecular Weight	334.35 g/mol
Synonyms	(Carbomethoxymethylene)triphenylphosphorane; Methyl 2-(triphenylphosphoranylidene)acetate; Methyl (triphenylphosphoranylidene)ethanoate; Triphenylphosphoranylideneacetic acid methyl ester; Wittig reagent methyl (triphenylphosphoranylidene)acetate; HWE reagent; Phosphorane, (carbomethoxymethylene)triphenyl-; Methyl P,P,P-triphenylphosphoranylideneacetate
EINECS	244-259-8

Quality Control

Our Methyl (Triphenylphosphoranylidene)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and titration methods, to ensure high chemical purity and consistent performance as a Wittig reagent. Comprehensive Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its sensitivity, the container should be kept under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and moisture uptake. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	168 - 172 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.