Description

tert-Butylphosphonothioic Dichloride is a versatile organophosphorus reagent characterized by its reactive dichloride and thiophosphoryl functional groups. This compound is a critical building block in synthetic organic chemistry, enabling the efficient introduction of the tert-butylphosphonothioate moiety into target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of phosphonothioate-containing drug candidates, including potential protease inhibitors and antiviral agents.
• Agrochemical Synthesis: Building block for creating novel herbicides, insecticides, and fungicides that incorporate phosphorothioate esters for enhanced biological activity.
• Ligand and Catalyst Preparation: Used to synthesize specialized phosphine-phosphonothioate ligands for asymmetric catalysis and metal complexation.
• Material Science Research: Intermediate in the development of flame retardants, polymer modifiers, and specialty additives where phosphorus-sulfur chemistry is required.
• Chemical Biology Probes: Employed in the creation of activity-based probes and bioconjugation reagents targeting enzymes like phosphatases and kinases.
• Process Chemistry: Scalable reagent for the industrial production of high-value, sulfur-containing fine chemicals.

Basic Information

Product Name	tert-Butylphosphonothioic Dichloride
CAS No.	21187-18-8
Molecular Formula	C₄H₉Cl₂PS
Molecular Weight	191.06 g/mol
Synonyms	tert-Butylphosphonothioic Dichloride; (tert-Butyl)phosphonothioic Dichloride; Phosphonothioic Dichloride, P-(1,1-Dimethylethyl)-; tert-Butylphosphonochloridothioate; 2-Methyl-2-propanephosphonothioic Dichloride; t-BuP(S)Cl₂; P-(tert-Butyl)phosphonothioic Dichloride
EINECS	Contact for details

Quality Control

Our tert-Butylphosphonothioic Dichloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced techniques including NMR, GC, and HPLC. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.