Description

4-Chlorobenzoic Acid [Carboxyl-14C] is a carbon-14 radiolabeled derivative of 4-chlorobenzoic acid, a key aromatic carboxylic acid. This isotopically labeled compound is essential for conducting precise metabolic and pharmacokinetic studies, providing critical data on the fate and distribution of chemical entities. It is primarily utilized by researchers and scientists in the pharmaceutical, agrochemical, and environmental sectors for advanced tracer applications, including drug metabolism research, environmental degradation studies, and biochemical pathway analysis.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiotracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of lead compounds and active pharmaceutical ingredients.
• Environmental Fate and Degradation Analysis: Employed in studies to trace the breakdown pathways and persistence of chlorinated aromatic compounds in ecosystems.
• Biochemical Pathway Elucidation: Serves as a labeled precursor or intermediate in research aimed at mapping specific metabolic routes in biological systems.
• Agrochemical Research: Applied in studies to understand the metabolic fate, residue analysis, and environmental impact of herbicides and pesticides containing chlorobenzoate motifs.
• Synthetic Intermediate for Labeled Compounds: Used in the synthesis of more complex carbon-14 labeled molecules for various research applications.
• Analytical Method Development: Acts as a standard in developing and validating sensitive analytical methods like LC-MS/MS for detecting trace compounds.

Basic Information

Product Name	4-Chlorobenzoic Acid [Carboxyl-14C]
CAS No.	21163-78-0
Molecular Formula	C7H5Cl14CO2H
Molecular Weight	~158.57 g/mol (for unlabeled); specific activity provided on COA.
Synonyms	p-Chlorobenzoic Acid-[carboxy-14C]; 4-Chloro[14C]benzoic Acid; [Carboxyl-14C]-4-Chlorobenzoic Acid; Benzoic-14C acid, 4-chloro-; 4-Chlorobenzoic-14C acid; p-Chloro[14C]benzoic Acid; 1-Carboxy-4-chlorobenzene-[carboxy-14C]
EINECS	Contact for details

Quality Control

Every batch of 4-Chlorobenzoic Acid [Carboxyl-14C] is produced and analyzed under strict quality protocols to ensure high chemical, radiochemical, and isotopic purity. Our quality assurance includes rigorous testing for identity, specific activity, and radiochemical purity, typically exceeding 98%. A comprehensive Certificate of Analysis (COA) detailing all specifications, including HPLC and radio-HPLC results, is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures (typically 2-8°C or as specified on the label) to maintain stability. Handle and store in accordance with all local, national, and international regulations for radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (Radio-HPLC)	≥ 98%
Specific Activity	Customizable; mCi/mmol range
Solvent (if supplied in solution)	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.