Description

(-)-Phenylnormetazocine Hydrochloride is a high-purity, enantiomerically pure benzomorphan derivative of significant interest in advanced pharmacological research. This compound serves as a critical reference standard and a key synthetic intermediate for the development and study of novel opioid receptor ligands. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and analytical testing facilities focused on neuropharmacology and medicinal chemistry.

Application

• Pharmacological Reference Standard: Used as a certified analytical standard for method development, validation, and quality control in pharmaceutical analysis.
• Medicinal Chemistry Research: Serves as a key chiral building block and precursor in the synthesis of novel opioid receptor-targeting compounds for structure-activity relationship (SAR) studies.
• Neuroscience Studies: Employed in in vitro and in vivo research to investigate the mechanisms of action, binding affinity, and functional activity at kappa (κ) and other opioid receptor subtypes.
• Analytical Method Development: Essential for developing and calibrating sensitive analytical techniques such as HPLC, LC-MS, and GC-MS for the detection and quantification of benzomorphan analogs.
• Impurity Profiling: Used to identify and quantify related substances and degradation products in active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	(-)-Phenylnormetazocine Hydrochloride
CAS No.	21141-28-6
Molecular Formula	C19H23NO•HCl
Molecular Weight	317.85 g/mol
Synonyms	(-)-5,9-Dimethyl-2'-hydroxy-2-phenethyl-6,7-benzomorphan Hydrochloride; (-)-N-Phenethylnormetazocine Hydrochloride; Phenylnormetazocine HCl; (-)-Phenylnormetazocine HCl; 2'-(–)-Hydroxy-5,9-dimethyl-2-phenethyl-6,7-benzomorphan Hydrochloride; (1R,9R)-1,9-Dimethyl-2-phenethyl-2'-hydroxy-6,7-benzomorphan Hydrochloride; MR 2034 (referring to the free base or related compound)
EINECS	Contact for details

Quality Control

Our (-)-Phenylnormetazocine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification, identity confirmation, and impurity profiling. A detailed Certificate of Analysis (COA) documenting the results is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (HPLC)	≥99.0% (enantiomeric excess)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.