Description

5-tert-Butyl-2-Chloro-1,3,2-Dioxaphosphorinane is a specialized organophosphorus compound, specifically a cyclic chlorophosphite ester. This chemical serves as a crucial intermediate and reagent in advanced synthetic chemistry, valued for its role in constructing complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials sectors for applications such as ligand synthesis and as a precursor to phosphorus-containing catalysts.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and prodrugs.
• Ligand Precursor: Used to prepare sophisticated phosphite and phosphoramidite ligands for asymmetric catalysis and cross-coupling reactions.
• Agrochemical Synthesis: Intermediate in the production of advanced pesticides and herbicides requiring specific stereochemistry.
• Polymer Modification: Acts as a monomer or modifying agent in the synthesis of flame-retardant or specialty polymers.
• Chemical Research: Valuable reagent in academic and industrial R&D for methodology development and exploring new reaction pathways.
• Catalyst Development: Serves as a precursor for homogeneous catalysts used in fine chemical and petrochemical processes.

Basic Information

Product Name	5-tert-Butyl-2-Chloro-1,3,2-Dioxaphosphorinane
CAS No.	21135-08-0
Molecular Formula	C7H14ClO2P
Molecular Weight	196.61 g/mol
Synonyms	2-Chloro-5-tert-butyl-1,3,2-dioxaphosphorinane; 5-(1,1-Dimethylethyl)-2-chloro-1,3,2-dioxaphosphorinane; tert-Butylchlorophosphite cyclic ethylene ester; 2-Chloro-5-tert-butyl-1,3,2-dioxaphosphorinane 2-oxide (common misnomer); Cyclic chlorophosphite ester; BCPE (abbreviation); Phosphorus heterocycle intermediate
EINECS	Contact for details

Quality Control

Every batch of 5-tert-Butyl-2-Chloro-1,3,2-Dioxaphosphorinane is manufactured under strict quality management systems. We employ advanced analytical techniques including NMR, HPLC, and GC to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.