Description

3-Chloro-1-Butyne is a versatile halogenated alkyne building block used in advanced organic synthesis. This compound is valued for its terminal alkyne and reactive chlorine functionalities, enabling a wide range of coupling and substitution reactions. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon for constructing complex molecular scaffolds in drug discovery and development.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators.
• Material Science: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers and functional materials.
• Organic Synthesis: A fundamental building block for Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating novel chemical entities.
• Ligand & Catalyst Development: Used to synthesize specialized ligands for metal complexes and catalysts.

Basic Information

Product Name	3-Chloro-1-Butyne
CAS No.	21020-24-6
Molecular Formula	C₄H₅Cl
Molecular Weight	88.54 g/mol
Synonyms	1-Butyne, 3-chloro-; 3-Chlorobut-1-yne; 3-Chloro-1-butyne; 3-Chlorobut-1-ine; Chlorobutylene; 3-Chloro-1-butine; 3-Chlorobutyne
EINECS	244-158-7

Quality Control

Our 3-Chloro-1-Butyne is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to verify identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.