Description

Deuterohemin is a stable, isotopically labeled porphyrin complex where the hydrogen atoms in the heme structure are replaced by deuterium. This compound is a critical biochemical and analytical standard, providing a non-radioactive, stable isotopic marker for advanced research. It is essential for scientists and manufacturers in the fields of biochemistry, analytical chemistry, and pharmaceutical research, particularly for use in mass spectrometry, NMR spectroscopy, and metabolic pathway tracing studies.

Application

• Internal Standard for Mass Spectrometry: Used as a stable isotope-labeled standard for the precise quantification of heme and related porphyrin compounds in complex biological matrices.
• Biochemical Research: Serves as a crucial tool in studying heme protein function, enzyme mechanisms (e.g., cytochromes P450), and oxygen-binding kinetics.
• Metabolic Pathway Analysis: Employed in tracer studies to investigate heme biosynthesis, degradation, and iron metabolism in living systems.
• Pharmaceutical Development: Utilized in the research and development of therapeutics targeting heme-related disorders and in drug metabolism studies.
• NMR Spectroscopy: Acts as a valuable probe in nuclear magnetic resonance studies due to the distinct properties of deuterium, aiding in structural elucidation.
• Diagnostic Reagent Manufacturing: Incorporated into the production of high-precision calibration standards and reagents for clinical diagnostic assays.

Basic Information

Product Name	Deuterohemin
CAS No.	21007-21-6
Molecular Formula	C34H28D4ClFeN4O4
Molecular Weight	652.0 g/mol (approx.)
Synonyms	Deuterohemin; Deuterated hemin; Iron deuteroporphyrin IX chloride; Deuterohaemin; [2,4-Dideutero-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(2-)-κN21,κN22,κN23,κN24]chloroiron; Deuterohemin chloride; Heme d4; Protohemin-d4; Ferriprotoporphyrin IX-d4 chloride
EINECS	Contact for details

Quality Control

Our Deuterohemin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment, chemical purity, and identity confirmation. We support research and industrial applications requiring reliable and traceable analytical standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	Dark brown to black crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment (D-content)	≥ 98 atom % D
Chloride Content	Conforms
Solubility	Soluble in dilute alkali, DMSO; insoluble in water
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.