Description

1-(5,10-Dihydro-4H-Benzo[5,6]Cyclohepta[1,2-B]Thiophen-4-Yl)-4-Methylpiperazine is a sophisticated heterocyclic organic compound featuring a fused tricyclic system, serving as a critical advanced intermediate in modern pharmaceutical synthesis. Its unique molecular architecture, combining a benzocycloheptathiophene core with a methylpiperazine moiety, makes it a valuable building block for creating novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. This high-purity intermediate is essential for research and development chemists and production teams in the pharmaceutical and fine chemical industries seeking to develop next-generation medications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the complex multi-step synthesis of proprietary APIs, leveraging its fused ring system for specific biological activity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fine Chemical Production: Employed in the manufacture of other high-value, complex specialty chemicals requiring this specific molecular framework.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for use in custom synthesis projects and scale-up development for clinical trial materials.

Basic Information

Product Name	1-(5,10-Dihydro-4H-Benzo[5,6]Cyclohepta[1,2-B]Thiophen-4-Yl)-4-Methylpiperazine
CAS No.	20977-53-1
Molecular Formula	C19H22N2S
Molecular Weight	310.46 g/mol
Synonyms	4-Methyl-1-(4H-benzo[5,6]cyclohepta[1,2-b]thiophen-4-yl)piperazine; 1-(4H-Benzo[5,6]cyclohepta[1,2-b]thiophen-4-yl)-4-methylpiperazine; 4-(4-Methylpiperazin-1-yl)-4H-benzo[5,6]cyclohepta[1,2-b]thiophene; Latrepirdine Intermediate; Dimebolin Intermediate; Dimebon Intermediate
EINECS	Contact for details

Quality Control

Our production of 1-(5,10-Dihydro-4H-Benzo[5,6]Cyclohepta[1,2-B]Thiophen-4-Yl)-4-Methylpiperazine adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical applications. All materials are characterized and released against comprehensive specifications, which include identity confirmation, assay, and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.