Description

Boc-Tyr-Osu CAS NO 20866-56-2 is a protected amino acid derivative, specifically N-(tert-Butoxycarbonyl)-L-tyrosine N-hydroxysuccinimide ester. This compound serves as a crucial building block in peptide synthesis, enabling the efficient and selective introduction of a tyrosine residue with its phenolic hydroxyl group protected. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for the development of peptide-based drugs, diagnostic agents, and biochemical research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the automated, stepwise construction of peptide chains, particularly for incorporating tyrosine.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions to form peptide bonds in solution, offering flexibility for specific synthetic routes.
• Bioconjugation and Labeling: Facilitates the covalent attachment of peptides to other molecules, surfaces, or reporter tags (e.g., fluorophores, biotin) for creating probes and conjugates.
• Pharmaceutical Intermediate: A critical raw material in the synthesis of active pharmaceutical ingredients (APIs) for peptide therapeutics targeting metabolic disorders, oncology, and cardiovascular diseases.
• Research & Development: Employed in academic and industrial R&D labs for exploring new peptide structures, studying protein-protein interactions, and developing novel bioactive compounds.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specific peptide sequences for clients.

Basic Information

Product Name	Boc-Tyr-Osu
CAS No.	20866-56-2
Molecular Formula	C₁₈H₂₂N₂O₇
Molecular Weight	378.38 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-tyrosine N-hydroxysuccinimide ester; Boc-L-tyrosine-OSu; Boc-Tyrosine-OSu; Boc-Tyr-OSu; N-Boc-L-tyrosine N-succinimidyl ester; Nα-Boc-L-tyrosine N-hydroxysuccinimide ester; (2,5-Dioxopyrrolidin-1-yl) (2S)-3-(4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate; N-Boc-O-benzyl-L-tyrosine-OSu (Note: This is a different, benzyl-protected derivative, but a common search alias).
EINECS	Contact for details

Quality Control

Our Boc-Tyr-Osu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability, consistency, and reliability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.