Description

trans-4-Bromo-1,1-dioxo-tetrahydrothiophen-3-ol is a high-purity, versatile sulfone derivative and brominated building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a bromine substituent and a sulfone group, makes it a critical intermediate for constructing complex molecules with precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for drug discovery and specialty chemical manufacturing.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for sulfone-containing drug candidates.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators where the sulfone moiety can enhance biological activity.
• Ligand & Catalyst Development: Acts as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Employed in the research of advanced polymers and functional materials with specific electronic or structural properties.
• Chemical Biology Probes: Useful for creating molecular probes to study enzyme mechanisms and biological pathways involving sulfur metabolism.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	trans-4-Bromo-1,1-dioxo-tetrahydrothiophen-3-ol
CAS No.	20688-40-8
Molecular Formula	C4H7BrO3S
Molecular Weight	215.07 g/mol
Synonyms	trans-4-Bromotetrahydrothiophene-3-ol 1,1-Dioxide; (3R,4S)-4-Bromotetrahydrothiophene-3-ol 1,1-Dioxide; 4-Bromo-1,1-dioxotetrahydro-3-thiophenol; 3-Thiophenanol, 4-bromotetrahydro-, 1,1-dioxide, trans-; 4-Bromotetrahydrothiophene-3-ol S,S-Dioxide; Brominated tetrahydrothiophene sulfone; THT sulfone bromo alcohol derivative.
EINECS	Contact for details

Quality Control

Our trans-4-Bromo-1,1-dioxo-tetrahydrothiophen-3-ol is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans-isomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.