Description

3,3-Di(Methyl-D 3 )-3H-Diazirine is a deuterated diazirine compound, a specialized photolabeling reagent used in advanced chemical and biochemical research. Its core value lies in its ability to generate highly reactive carbene intermediates upon photolysis, enabling precise covalent cross-linking for studying molecular interactions and structures. This product is essential for researchers in pharmaceutical development, proteomics, and structural biology who require high-purity, isotopically labeled probes for mass spectrometry-based analysis.

Application

• Photoaffinity Labeling (PAL): A critical tool for mapping binding sites and identifying molecular targets of bioactive compounds in drug discovery.
• Cross-linking Mass Spectrometry (XL-MS): Used to investigate protein-protein interactions and protein structures by creating covalent bonds between interacting molecules.
• Proteomics Research: Enables the study of protein function, dynamics, and interaction networks within complex biological systems.
• Isotope Labeling: The deuterium (D) labeling facilitates tracking and quantification in mass spectrometric analysis, improving detection sensitivity and accuracy.
• Materials Science: Potential use in surface modification and the creation of novel polymeric materials via carbene insertion chemistry.

Basic Information

Product Name	3,3-Di(Methyl-D 3 )-3H-Diazirine
CAS No.	20686-76-4
Molecular Formula	C3D6N2
Molecular Weight	76.12 g/mol
Synonyms	3,3-Bis(trideuteriomethyl)diaziridine; Perdeuterated 3,3-Dimethyldiazirine; D6-3,3-Dimethyldiazirine; 3,3-Di(trideuteriomethyl)diazirine; Diazirine-D6; (Trideuteriomethyl)(trideuteriomethyl)diazene; Photoaffinity Labeling Reagent D6
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our deuterated reagents. Each batch of 3,3-Di(Methyl-D 3 )-3H-Diazirine is analyzed to ensure high isotopic purity and chemical integrity, critical for sensitive research applications. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and identity are provided with every shipment. Our quality system is designed to support research requiring the highest levels of traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at recommended room temperature (15-25°C). Due to its light-sensitive nature and potential volatility, containers should be kept sealed and handled in a controlled environment to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment (D)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.