Description

2α-Chlorocyclobutanone CAS NO 20686-67-3 is a versatile and reactive chlorinated ketone building block, essential for advanced organic synthesis. Its strained cyclobutanone ring and reactive α-chloro ketone functionality make it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of cyclobutane-containing drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its reactive site for ring expansion and functionalization.
• Organic Synthesis Reagent: Serves as a precursor for [2+2] cycloaddition reactions and other ring-opening/ring-expansion transformations to access strained and functionalized carbocycles.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with unique thermal or mechanical properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and labeled compounds for studying biological mechanisms and enzyme inhibition.

Basic Information

Product Name	2α-Chlorocyclobutanone
CAS No.	20686-67-3
Molecular Formula	C4H5ClO
Molecular Weight	104.54 g/mol
Synonyms	2-Chlorocyclobutanone; α-Chlorocyclobutanone; 2-Chloro-cyclobutanone; Cyclobutanone, 2-chloro-; 2-Chlorocyclobutan-1-one
EINECS	Contact for details

Quality Control

Our 2α-Chlorocyclobutanone is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your R&D and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature, handling should be performed under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.