Description

Ammonium Acetate-D3 is a deuterium-labeled analog of ammonium acetate, a versatile reagent and buffer component. This isotopically labeled compound is essential for applications requiring precise tracking and quantification, such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. It is primarily used by researchers and quality control laboratories in the pharmaceutical, biotechnology, and analytical chemistry sectors for method development, internal standardization, and metabolic studies.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard in quantitative bioanalytical methods for accurate pharmacokinetic and metabolomic studies.
• NMR Spectroscopy Solvent/Reagent: Serves as a deuterated reagent or buffer component in NMR experiments to minimize solvent interference and provide a deuterium lock signal.
• Metabolic Pathway Tracing: Employed in research to trace acetate metabolism in biological systems using deuterium as a non-radioactive tracer.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants in drug substances and products.
• Buffer Component in Deuterated Systems: Functions as a buffering agent in specialized chemical and biochemical reactions performed in deuterated solvents.
• Chemical Synthesis Intermediate: Acts as a labeled building block or catalyst in the synthesis of deuterated organic compounds and active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Ammonium Acetate-D3
CAS No.	20515-38-2
Molecular Formula	C2D3NO2 or CD3COOND4
Molecular Weight	80.11 g/mol (for C2D3NO2)
Synonyms	Acetic-d3 acid, ammonium salt; Deuterated ammonium acetate; Ammonium acetate-d3; Ammonium tri-deuteroacetate; Ammonium (2,2,2-trideutero)acetate; [2H3]-Ammonium acetate; ND4OOCD3
EINECS	Contact for details

Quality Control

Our Ammonium Acetate-D3 is manufactured under controlled conditions to ensure high isotopic and chemical purity suitable for sensitive analytical applications. Each batch is analyzed to confirm deuterium enrichment, assay, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing isotopic purity (D-atom %), chemical purity, residual solvents, and other relevant parameters is provided with every shipment to ensure traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive). Store in a cool, dry place at room temperature (15-25°C). For long-term stability, consider storage under an inert atmosphere in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR / NMR)	Conforms to structure
Isotopic Purity (D-atom %)	≥ 98% (or as specified)
Assay (Titration)	≥ 98.0%
Deuterium Enrichment (NMR/MS)	≥ 99% at labeled positions
pH (5% solution)	6.5 - 7.5
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.