Description

[S,(+)]-2-Butanethiol CAS NO 20407-74-3 is a high-purity, chiral organosulfur compound characterized by its distinct thiol functional group and specific optical rotation. This enantiomerically enriched material is critical for applications requiring precise stereochemical control, such as in advanced pharmaceutical synthesis and the development of chiral ligands or catalysts. It serves as a valuable building block and intermediate for researchers and manufacturers in the fine chemical, pharmaceutical, and agrochemical industries seeking to incorporate chiral sulfur motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates requiring specific stereochemistry.
• Chiral Ligand & Catalyst Synthesis: Used in the preparation of enantioselective catalysts and ligands for asymmetric synthesis in research and industrial processes.
• Flavor & Fragrance Industry: Serves as a precursor for synthesizing specific sulfur-containing aroma compounds, contributing to complex flavor profiles.
• Agrochemical Research: Intermediate in the development of novel pesticides and herbicides where the chiral center influences biological activity.
• Material Science: Employed in the synthesis of functionalized polymers and materials with tailored surface properties.
• Organic Synthesis & Research: A versatile reagent for introducing the chiral sec-butylthio group in various nucleophilic substitution and addition reactions.

Basic Information

Product Name	[S,(+)]-2-Butanethiol
CAS No.	20407-74-3
Molecular Formula	C4H10S
Molecular Weight	90.19 g/mol
Synonyms	(S)-(+)-2-Butanethiol; (S)-2-Butyl mercaptan; (S)-sec-Butyl mercaptan; (S)-1-Methyl-1-propanethiol; Dextrorotatory 2-Butanethiol; (2S)-Butane-2-thiol; (S)-Butane-2-thiol; (+)-sec-Butyl mercaptan
EINECS	Contact for details

Quality Control

Our [S,(+)]-2-Butanethiol is produced under stringent quality management systems. Each batch is rigorously tested to ensure high chemical and enantiomeric purity, with specifications typically covering identity, assay, optical rotation, and impurity profiles via techniques such as GC, HPLC, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) in a cool, well-ventilated place, away from heat, sparks, and open flame. Due to its highly volatile and easily oxidized nature, the container should be kept tightly sealed and at a consistent, cool temperature (recommended 2-8°C for long-term storage). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Enantiomeric Excess (Chiral GC/HPLC)	≥ 99.0% ee
Specific Optical Rotation [α]	+ / - Value provided on COA
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.