Description

2-Chloro-1,3,2-oxathiaphospholane is a versatile organophosphorus reagent featuring a reactive cyclic structure. This compound is valued for its role as a key intermediate in the synthesis of modified nucleotides and other biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced organic synthesis and medicinal chemistry.

Application

• Phosphoramidite Synthesis: A critical building block in the preparation of nucleoside phosphoramidites for automated oligonucleotide (DNA/RNA) synthesis.
• Medicinal Chemistry: Serves as an intermediate in the development of prodrugs and novel therapeutic agents targeting various disease pathways.
• Chemical Biology Research: Used to introduce phosphate or thiophosphate analogs into biomolecules for structure-activity relationship (SAR) studies and probe development.
• Polymer Chemistry: Can act as a monomer or modifying agent in the synthesis of specialized polymers with tailored properties.
• Agrochemical Intermediates: Employed in the research and development of new pesticides and plant growth regulators.
• Ligand and Catalyst Preparation: Useful for synthesizing chiral phosphorus-containing ligands used in asymmetric catalysis.

Basic Information

Product Name	2-Chloro-1,3,2-oxathiaphospholane
CAS No.	20354-32-9
Molecular Formula	C2H4ClOPS
Molecular Weight	142.54 g/mol
Synonyms	2-Chloro-2-oxo-1,3,2-oxathiaphospholane; 2-Chloro-1,3,2-oxathiaphospholane 2-oxide; 2-Chloro-2-oxo-1,3,2-oxathiaphosphacyclopentane; Chloro(ethylene sulfite)phosphorane; Ethylene chlorophosphorothioite S-oxide; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 2-Chloro-1,3,2-oxathiaphospholane is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in research and development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.