Description

tert-Butyl 2-Mercaptoacetate is a versatile sulfur-containing ester, specifically the tert-butyl ester of 2-mercaptoacetic acid. This compound is valued as a key building block and protecting group reagent in sophisticated organic synthesis, particularly for the introduction of thiol functionalities. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: Serves as a crucial synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those containing thioether or disulfide linkages.
• Peptide Chemistry: Used as a protecting group for cysteine residues during solid-phase peptide synthesis (SPPS) to prevent unwanted disulfide bond formation.
• Agrochemical Synthesis: Acts as a precursor in the manufacturing of certain herbicides, fungicides, and insecticides that incorporate sulfur-based bioactive moieties.
• Ligand and Catalyst Preparation: Employed in the synthesis of sulfur-donor ligands for metal complexes used in catalysis and material science.
• Polymer Modification: Utilized to introduce thiol groups into polymer chains for subsequent cross-linking or functionalization via thiol-ene "click" chemistry.
• Flavor and Fragrance Industry: May serve as an intermediate for the synthesis of certain sulfur-containing aroma compounds.

Basic Information

Product Name	tert-Butyl 2-Mercaptoacetate
CAS No.	20291-99-0
Molecular Formula	C6H12O2S
Molecular Weight	148.22 g/mol
Synonyms	2-Mercaptoacetic Acid tert-Butyl Ester; tert-Butyl Thioglycolate; (tert-Butoxycarbonyl)methanethiol; Acetic Acid, 2-Mercapto-, 1,1-Dimethylethyl Ester; TBTA; t-Butyl Mercaptoacetate; NSC 334365
EINECS	243-693-9

Quality Control

Our tert-Butyl 2-Mercaptoacetate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopic methods, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider keeping under an inert atmosphere (e.g., nitrogen or argon) to maintain optimal purity and shelf life. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.