Description

N,n-Dimethylformamide-1-D is a deuterated isotopologue of the widely used polar aprotic solvent dimethylformamide (DMF), specifically labeled with deuterium at the formyl position. This compound is essential for advanced research and analytical applications where isotopic labeling is required to study reaction mechanisms, metabolic pathways, or to serve as an internal standard in spectroscopic techniques like NMR and mass spectrometry. It is a critical material for pharmaceutical R&D, academic research in synthetic chemistry, and specialized industrial processes in the fine chemical and electronics sectors.

Application

• As a deuterated solvent for Nuclear Magnetic Resonance (NMR) spectroscopy, providing a non-interfering signal for structural analysis of organic compounds.
• As a labeled reagent or solvent in reaction mechanism studies and kinetic isotope effect (KIE) investigations in synthetic organic chemistry.
• Use as an internal standard or reference material in quantitative mass spectrometry (MS) and liquid chromatography-mass spectrometry (LC-MS) for accurate calibration.
• Application in the synthesis of deuterium-labeled pharmaceutical intermediates and active pharmaceutical ingredients (APIs) for drug metabolism and pharmacokinetics (DMPK) studies.
• Utilization in materials science research, particularly in the development of organic semiconductors and electronic materials where isotopic purity can influence properties.
• As a specialty solvent in photochemical and electrochemical research where standard protonated solvents may interfere with sensitive measurements.

Basic Information

Product Name	N,n-Dimethylformamide-1-D
CAS No.	2914-27-4
Molecular Formula	C3H6DNO
Molecular Weight	74.11 g/mol
Synonyms	Deuterated DMF; DMF-d1; N,N-Dimethylformamide-d1; (Dimethylamino)(2H)methanone; Formamide-d, N,N-dimethyl-; N,N-Dimethylformamide (formyl-D); Deuterated N,N-Dimethylformamide
EINECS	220-841-8

Quality Control

Our N,n-Dimethylformamide-1-D is produced and handled under stringent quality protocols to ensure high isotopic and chemical purity suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic purity (D atom %), chemical purity by GC or HPLC, water content (Karl Fischer), and NMR spectroscopy verification. We adhere to relevant industry standards for high-purity reagents, and specifications can be tailored to meet specific research or GMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect isotopic purity and chemical stability. Keep away from strong oxidizing agents and acids.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms
Isotopic Purity (D atom %)	≥ 98.0%
Chemical Purity (GC)	≥ 99.5%
Water Content (KF)	≤ 0.1%
NMR Verification	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.