Description

5-Iodo-2-Methylbenzimidazole is a halogenated benzimidazole derivative, a versatile heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its iodine substituent, which provides a reactive handle for further functionalization via cross-coupling reactions, making it a critical intermediate for creating complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting various enzyme systems where the benzimidazole scaffold is prevalent.
• Agrochemical Research: Used in the development of new fungicides, herbicides, and plant growth regulators that utilize halogenated heterocycles for enhanced bioactivity.
• Material Science: Serves as a building block for organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its planar, conjugated structure and halogen atom.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to create biaryl and extended π-systems.
• Chemical Biology & Proteomics: Can be used to create affinity probes or tags for studying protein-ligand interactions and cellular processes.
• Coordination Chemistry: Acts as a ligand for transition metals, forming complexes with potential catalytic or luminescent properties.

Basic Information

Product Name	5-Iodo-2-Methylbenzimidazole
CAS No.	2818-70-4
Molecular Formula	C8H7IN2
Molecular Weight	258.06 g/mol
Synonyms	2-Methyl-5-iodobenzimidazole; 5-Iodo-2-methyl-1H-benzimidazole; 1H-Benzimidazole, 5-iodo-2-methyl-; 2818-70-4; 5-Iodo-2-methylbenzimidazole; 2-Methyl-5-iodo-1H-benzimidazole
EINECS	Contact for details

Quality Control

Our 5-Iodo-2-Methylbenzimidazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.