Description

L-Glutamic-2,3,3,4,4-D5 Acid is a stable isotope-labeled analog of L-glutamic acid, where five hydrogen atoms are replaced by deuterium at specific positions. This high-purity labeled compound is essential for advanced analytical and research applications requiring precise molecular tracking and quantification. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and metabolic research sectors.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of endogenous glutamic acid levels in complex biological matrices.
• Metabolic Pathway Tracing: Used in NMR and MS-based studies to elucidate metabolic fluxes, enzyme mechanisms, and neurotransmitter cycling in neuroscience and cell biology research.
• Pharmaceutical Drug Metabolism & Pharmacokinetics (DMPK): Employed in the development and validation of bioanalytical methods for tracking drug metabolites and studying amino acid-related pharmacokinetics.
• Biochemical Research Reagent: Acts as a labeled precursor or substrate in enzymatic assays and studies of glutamate dehydrogenase, transaminases, and other related enzymes.
• Quality Control & Method Development: Provides a stable isotope-labeled benchmark for ensuring accuracy, precision, and compliance in analytical laboratories within regulated environments.

Basic Information

Product Name	L-Glutamic-2,3,3,4,4-D5 Acid
CAS No.	2784-50-1
Molecular Formula	C5H4D5NO4
Molecular Weight	152.15 g/mol
Synonyms	(2S)-2-Aminopentanedioic-2,3,3,4,4-d5 Acid; L-Glutamic Acid-d5; (S)-2-Aminoglutaric-2,3,3,4,4-d5 Acid; Deuterated L-Glutamic Acid; L-Glutamic-2,3,3,4,4-d5 Acid; Glutamic Acid-2,3,3,4,4-d5 (L-form); (S)-1-Amino-1,3-dicarboxypropane-2,3,3,4,4-d5; Stable Isotope Labeled Glutamate
EINECS	Contact for details

Quality Control

Our L-Glutamic-2,3,3,4,4-D5 Acid is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, critical for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (atom % D), chemical purity, and specific analytical results. We adhere to relevant industry standards for high-purity research chemicals, ensuring reliability and consistency for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % D)	≥ 98.0% (by MS)
Optical Rotation	[α]20/D: +30.0° to +33.0° (c=1 in 1N HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.