Description

1,1,1-Trichloroethane (2,2,2-D3) is a deuterated isotopologue of the common solvent 1,1,1-trichloroethane, where three hydrogen atoms are replaced by deuterium. This compound is a critical analytical standard and tracer used in advanced research and quality control, offering enhanced spectral resolution and stability in sensitive detection methods. It is essential for scientists and quality assurance professionals in the pharmaceutical, environmental, and chemical synthesis industries who require precise internal standards for mass spectrometry, NMR spectroscopy, and reaction mechanism studies.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in GC-MS and LC-MS analysis for environmental monitoring and metabolomics.
• NMR Spectroscopy Solvent & Tracer: Serves as a deuterated solvent or a mechanistic tracer in nuclear magnetic resonance studies to elucidate reaction pathways.
• Pharmaceutical Impurity Profiling: Employed in the identification and quantification of process-related impurities and degradation products in API development.
• Environmental Fate Studies: Acts as a stable isotopic tracer to study the degradation, metabolism, and transport of chlorinated solvents in ecological systems.
• Chemical Synthesis Research: Utilized in kinetic isotope effect (KIE) studies to investigate reaction mechanisms and transition states in organic chemistry.
• Quality Control & Method Validation: Provides a certified reference material for calibrating instruments and validating analytical methods in compliance with GLP/GMP.

Basic Information

Product Name	1,1,1-Trichloroethane (2,2,2-D3)
CAS No.	2747-58-2
Molecular Formula	C2D3Cl3
Molecular Weight	136.41 g/mol
Synonyms	Deuterated 1,1,1-Trichloroethane; 1,1,1-Trichloroethane-d3; Methylchloroform-d3; Trichloro-d3-ethane; α,α,α-Trichloroethane-d3; NSC 405124; RCRA waste number U226; 2,2,2-Trichloroethane-d3
EINECS	220-396-4

Quality Control

Every batch of our 1,1,1-Trichloroethane (2,2,2-D3) is produced and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including assay, isotopic enrichment (D-atom %), and impurity profiling by GC and NMR. Certificates of Analysis (COA) detailing all specifications are provided and traceable to certified reference materials, supporting compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat sources and incompatible materials such as strong bases and active metals. Due to its highly volatile nature, ensure containers are kept upright and sealed when not in use. Recommended storage temperature is 2-8°C to maximize stability.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 99.0% (Chemical Purity)
Isotopic Enrichment	≥ 99.0 atom % D
Water Content (KF)	≤ 0.1%
Residue on Evaporation	≤ 0.01%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.