Description

Tetrahydrofuran-3,3,4,4-D4 is a deuterated analog of tetrahydrofuran, specifically labeled on the 3 and 4 positions. This compound is essential for advanced research and development where isotopic labeling is required to study reaction mechanisms, metabolic pathways, or for use as an internal standard in analytical techniques. It is primarily utilized by researchers and process development scientists in the pharmaceutical, agrochemical, and academic sectors who require high-purity, isotopically labeled solvents and reagents for spectroscopic studies, including NMR and mass spectrometry.

Application

• NMR Spectroscopy Solvent: Used as a deuterated solvent for nuclear magnetic resonance (NMR) spectroscopy, providing a non-interfering signal for analyzing organic compounds.
• Mass Spectrometry Internal Standard: Serves as a critical internal standard in quantitative mass spectrometry (MS) and liquid chromatography-mass spectrometry (LC-MS) for accurate measurement of analytes.
• Mechanistic Studies: Employed in reaction mechanism elucidation and kinetic isotope effect (KIE) studies within pharmaceutical and chemical research.
• Metabolic Pathway Tracing: Utilized in pharmaceutical development for tracing the metabolic fate of drug candidates in biological systems.
• Polymer Chemistry Research: Acts as a labeled monomer or solvent in the study of polymerization mechanisms and polymer structure analysis.
• Advanced Material Synthesis: Used in the synthesis of deuterated materials for specialized applications in electronics and optics.

Basic Information

Product Name	Tetrahydrofuran-3,3,4,4-D4
CAS No.	2717-68-2
Molecular Formula	C4D4H4O
Molecular Weight	76.13 g/mol
Synonyms	THF-d4 (3,3,4,4); [3,3,4,4-2H4]Tetrahydrofuran; Tetrahydrofuran-d4 (asymmetric); Perdeuterated Tetrahydrofuran (partial); Deuterated THF; Oxolane-d4; 1,4-Epoxybutane-d4; Tetramethylene oxide-d4
EINECS	Contact for details

Quality Control

Our Tetrahydrofuran-3,3,4,4-D4 is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR, GC, and Karl Fischer titration, to ensure high isotopic purity and chemical purity suitable for sensitive spectroscopic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with the specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area at a controlled room temperature (15-25°C). Due to its highly volatile nature, keep away from heat, sparks, and open flame. Ensure containers are kept tightly sealed when not in use to prevent evaporation and potential contamination.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (NMR)	Conforms to structure
Isotopic Purity (D)	≥ 99.0 atom % D
Chemical Purity (GC)	≥ 99.5%
Water Content (KF)	≤ 0.05%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.