Description

Levopropoxyphene is a synthetic opioid analgesic and antitussive agent, chemically related to methadone. It is a critical intermediate in pharmaceutical synthesis and a key reference standard for analytical and research purposes. This compound is essential for pharmaceutical manufacturers, research institutions, and quality control laboratories engaged in drug development, forensic analysis, and regulatory compliance.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) for cough suppressants and pain management.
• Analytical Reference Standard: Used in high-performance liquid chromatography (HPLC), gas chromatography (GC), and mass spectrometry (MS) for method development, validation, and quality control testing.
• Pharmacological Research: Employed in preclinical studies to investigate opioid receptor activity, metabolic pathways, and structure-activity relationships (SAR).
• Forensic Analysis: Acts as a certified reference material (CRM) for the identification and quantification of substances in forensic toxicology.
• Impurity Standard: Used to identify, quantify, and control process-related impurities and degradation products in pharmaceutical formulations.
• Regulatory Compliance: Supports compliance testing for regulatory submissions to agencies such as the FDA and EMA.

Basic Information

Product Name	Levopropoxyphene
CAS No.	2338-37-6
Molecular Formula	C22H29NO2
Molecular Weight	339.48 g/mol
Synonyms	(-)-Propoxyphene; Levopropoxyphene Napsylate; Levopropoxyphene Hydrochloride; (2S,3R)-4-(Dimethylamino)-3-methyl-1,2-diphenyl-2-butanol Propanoate; d-Propoxyphene; Novrad; α-d-Propoxyphene; Contact for details on additional synonyms.
EINECS	219-058-6

Quality Control

Our Levopropoxyphene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and GC-MS, to ensure it meets the stringent requirements for pharmaceutical intermediates and reference standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.