Description

Diisopropylchlorosilane is a highly reactive organosilicon compound primarily used as a key building block in organic synthesis and materials science. Its value lies in its ability to introduce the diisopropylsilyl protecting group, offering superior steric bulk and stability for sensitive synthetic intermediates. This chemical is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise molecular modification and protection strategies. Its controlled reactivity makes it a critical reagent for developing novel silicon-based polymers and fine chemicals.

Application

• Protecting Group Reagent: Widely used in multi-step organic synthesis to protect hydroxyl groups (as diisopropylsilyl ethers), offering excellent stability under a variety of reaction conditions.
• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) and complex drug molecules requiring selective protection/deprotection sequences.
• Agrochemical Synthesis: Employed in the manufacturing of advanced pesticides, herbicides, and fungicides where silicon incorporation enhances biological activity or stability.
• Silicone Polymer Modification: Acts as a monomer or cross-linking agent in the production of specialty silicones, influencing polymer backbone properties and functionality.
• Surface Functionalization: Used to modify the surface of silica, glass, or other oxides, creating hydrophobic or specific reactive interfaces for advanced materials.
• Laboratory Research & Development: A fundamental reagent in academic and industrial R&D for exploring new organosilicon chemistry and developing novel synthetic methodologies.

Basic Information

Product Name	Diisopropylchlorosilane
CAS No.	2227-29-4
Molecular Formula	C6H15ClSi
Molecular Weight	150.72 g/mol
Synonyms	Chlorodiisopropylsilane; Diisopropylchlorosilane; Diisopropylsilyl chloride; Silane, chlorodiisopropyl-; Chlorodi-2-propylsilane; (CH3)2CH)2SiHCl; Di-iso-propylchlorosilane; NSC 66155
EINECS	218-767-7

Quality Control

Our Diisopropylchlorosilane is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, NMR, and titration methods, to verify identity, assay, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials. Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent hydrolysis. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Density (at 20°C)	0.88 - 0.92 g/mL
Refractive Index (n20D)	1.425 - 1.435
Water Content (Karl Fischer)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.