Description

4,5α-Epoxy-3-Methoxy-17-Methylmorphinan-8β-Ol Acetate is a high-purity synthetic opioid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of specialized analgesics and for pharmacological studies targeting the central nervous system. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers requiring precise and reliable building blocks for complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent analgesic agents and other specialized opioid receptor ligands.
• Reference Standard: Used in analytical laboratories as a high-purity standard for method development, quality control (QC), and regulatory compliance testing of related pharmaceutical products.
• Biochemical Research: Employed in preclinical studies to investigate opioid receptor binding affinity, pharmacokinetics, and structure-activity relationships (SAR).
• Process Chemistry Development: Serves as a model compound for optimizing synthetic routes, scaling up production, and developing purification protocols in fine chemical manufacturing.

Basic Information

Product Name	4,5α-Epoxy-3-Methoxy-17-Methylmorphinan-8β-Ol Acetate
CAS No.	2202-08-6
Molecular Formula	C21H27NO4
Molecular Weight	357.45 g/mol
Synonyms	8β-Acetoxy-4,5α-epoxy-3-methoxy-17-methylmorphinan; 8β-Hydroxy-4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one acetate (ester); 8β-Acetoxy-4,5-epoxy-3-methoxy-17-methylmorphinan; 8β-Acetoxy-3-methoxy-17-methyl-4,5α-epoxymorphinan; Noroxymorphone acetate derivative; 8-Acetoxy-3-methoxy-17-methyl-4,5α-epoxymorphinan
EINECS	Contact for details

Quality Control

Our 4,5α-Epoxy-3-Methoxy-17-Methylmorphinan-8β-Ol Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.