Description

5-Bromothiophene-2-Carbonitrile is a versatile brominated heterocyclic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both a bromine substituent and a nitrile group on a thiophene core, makes it a critical precursor for constructing complex molecules. This high-purity intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, leveraging its reactive sites for structural diversification.
• Material Science Precursor: Serves as a building block for the synthesis of functional polymers, organic semiconductors, and liquid crystals.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl and conjugated systems.
• Nitrile Functionalization: The cyano group can be transformed into amides, acids, tetrazoles, and other nitrogen-containing heterocycles, expanding its utility.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	5-Bromothiophene-2-Carbonitrile
CAS No.	2160-62-5
Molecular Formula	C5H2BrNS
Molecular Weight	187.04 g/mol
Synonyms	2-Bromo-5-cyanothiophene; 5-Bromo-2-thiophenecarbonitrile; 2-Cyano-5-bromothiophene; 5-Bromothiophene-2-carbonitrile; Thiophene-2-carbonitrile, 5-bromo-; 5-Bromo-2-thienyl cyanide; 2-Thiophenecarbonitrile, 5-bromo-
EINECS	218-489-7

Quality Control

Our 5-Bromothiophene-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. The compound is light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.