Description

Ethyl 5-Bromo-4-Nitrothiophene-2-Carboxylate is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is valued for its reactive bromo and nitro substituents on the thiophene core, enabling precise molecular construction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries to create novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory pathways.
• Agrochemical Synthesis: Serves as a critical building block for developing new-generation herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Used in the development of organic semiconductors, conductive polymers, and non-linear optical (NLO) materials due to its electron-deficient thiophene structure.
• Dye & Pigment Chemistry: Acts as an intermediate for synthesizing specialized heterocyclic dyes and pigments with unique color properties and lightfastness.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings for carbon-carbon bond formation.
• Nucleophilic Aromatic Substitution: The activated nitro group allows for selective functionalization, enabling the introduction of amines and other nucleophiles.

Basic Information

Product Name	Ethyl 5-Bromo-4-Nitrothiophene-2-Carboxylate
CAS No.	2160-52-3
Molecular Formula	C7H6BrNO4S
Molecular Weight	280.10 g/mol
Synonyms	5-Bromo-4-nitro-2-thiophenecarboxylic acid ethyl ester; Ethyl 5-bromo-4-nitro-2-thiophenecarboxylate; 2-Thiophenecarboxylic acid, 5-bromo-4-nitro-, ethyl ester; 5-Bromo-4-nitrothiophene-2-carboxylic acid ethyl ester; 2160-52-3; Ethyl 5-bromo-4-nitrothiophene-2-carboxylate; NSC 163044
EINECS	Contact for details

Quality Control

Our Ethyl 5-Bromo-4-Nitrothiophene-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.