Description

2,2,8,8-Tetramethyl-5,5-Bis[[(Trimethylsilyl)Oxy]Methyl]-3,7-Dioxa-2,8-Disilanonane is a specialized organosilicon compound, specifically a silyl ether derivative, valued for its role as a versatile protecting group and building block in advanced organic synthesis. Its structure, featuring multiple trimethylsilyl (TMS) groups, makes it a critical reagent for the protection of hydroxyl functionalities, particularly in the synthesis of complex molecules where selective deprotection is required. This high-purity chemical is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for sensitive synthetic pathways.

Application

• Pharmaceutical Intermediate: Used as a key protecting group reagent in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for sensitive alcohol groups.
• Agrochemical Synthesis: Serves as a building block in the production of advanced pesticides and herbicides where selective protection of hydroxyl groups is necessary.
• Organic Synthesis Reagent: A valuable tool in academic and industrial research laboratories for the construction of complex natural products and novel organic molecules.
• Specialty Polymer & Material Science: Employed in the synthesis of silicone-based polymers and advanced materials requiring specific silyl ether linkages.
• Peptide & Carbohydrate Chemistry: Facilitates the selective protection of hydroxyl groups during the synthesis of peptides, sugars, and nucleosides.

Basic Information

Product Name	2,2,8,8-Tetramethyl-5,5-Bis[[(Trimethylsilyl)Oxy]Methyl]-3,7-Dioxa-2,8-Disilanonane
CAS No.	2114-25-2
Molecular Formula	C16H42O4Si4
Molecular Weight	434.90 g/mol
Synonyms	1,1,1,3,5,7,7,7-Octamethyl-3,5-bis(trimethylsiloxy)tetrasiloxane; Tetrakis(trimethylsiloxy)silane (specific isomer); 3,5-Bis(trimethylsiloxy)-1,1,1,3,5,7,7,7-octamethyltetrasiloxane; Bis(trimethylsiloxy)methylsilane dimer; TMS-protected silanol dimer; Silicon ether protecting agent; CAS 2114-25-2
EINECS	Contact for details

Quality Control

Our 2,2,8,8-Tetramethyl-5,5-Bis[[(Trimethylsilyl)Oxy]Methyl]-3,7-Dioxa-2,8-Disilanonane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support its use in regulated synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.