Description

Blasticidin S is a potent nucleoside antibiotic isolated from *Streptomyces griseochromogenes*. This compound is valued for its selective inhibitory action against prokaryotic and eukaryotic protein synthesis, making it a critical tool in molecular biology and agricultural research. It is primarily utilized by researchers in biotechnology, pharmaceutical development, and plant science for applications requiring precise genetic selection.

Application

• Cell Culture Selection Agent: Widely used as a selective antibiotic in mammalian, plant, and bacterial cell culture systems to maintain plasmids containing the blasticidin S resistance gene (bsr).
• Molecular Biology Research: Essential for stable transfection experiments, gene knockout/knock-in studies, and the establishment of stable cell lines expressing recombinant proteins.
• Plant Biotechnology: Employed as a selective marker in the transformation of various plant species, including rice, tobacco, and Arabidopsis.
• Fungicidal Activity: Demonstrates efficacy against rice blast fungus (*Pyricularia oryzae*) and serves as a model compound in antifungal research and agrochemical development.
• Virology Studies: Used in research involving viral vectors (e.g., baculovirus) where the blasticidin resistance gene is incorporated as a selectable marker.
• High-Throughput Screening (HTS): Applied in drug discovery platforms to screen for novel antimicrobial or anticancer agents that target protein synthesis.

Basic Information

Product Name	Blasticidin S
CAS No.	2079-00-7
Molecular Formula	C17H26N8O5
Molecular Weight	422.44 g/mol
Synonyms	Blasticidin S Hydrochloride (common salt form); Bla-S; Antibiotic 2079; NSC 324554; 1-((4-Amino-2-oxo-1(2H)-pyrimidinyl)carbonyl)-3-(3-amino-5-methyl-2-oxo-1(2H)-pyrazinyl)-2,4,5,6-tetradeoxy-L-*erythro*-hex-2-enonic acid δ-lactam; Blasticidin S from *Streptomyces griseochromogenes*
EINECS	218-204-6

Quality Control

Our Blasticidin S is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent limits for residual solvents and endotoxins where applicable. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research-grade standards and support your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Potency (Microbiological)	≥ 800 µg/mg
Endotoxin (LAL)	< 10 EU/mg (for cell culture grade)
Solubility	Soluble in water, methanol; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.