Description

Toluene-D8 is a deuterated isotopologue of toluene, where all eight hydrogen atoms are replaced by deuterium (²H). This high-purity, isotopically labeled compound is an essential internal standard and solvent for advanced analytical techniques, particularly Nuclear Magnetic Resonance (NMR) spectroscopy. It is critical for researchers and quality control laboratories in the pharmaceutical, chemical, and academic sectors who require precise, interference-free measurements and reliable quantitative analysis.

Application

• NMR Spectroscopy: Primary use as a deuterated solvent for locking and shimming, providing a stable, non-interfering signal for high-resolution ¹H and ¹³C NMR analysis.
• Mass Spectrometry (MS): Employed as an internal standard for the accurate quantification of toluene and related aromatic compounds in GC-MS and LC-MS methods.
• Chemical Reaction Studies: Used as a tracer or starting material in mechanistic studies and kinetic isotope effect (KIE) investigations to elucidate reaction pathways.
• Pharmaceutical Research: Critical in drug metabolism and pharmacokinetics (DMPK) studies for tracking and quantifying metabolites using stable isotope labeling.
• Environmental Analysis: Serves as a reference standard for the detection and measurement of toluene contamination in air, water, and soil samples.
• Polymer Science: Used in the analysis of polymer composition and structure via NMR, where protonated solvents would obscure key signals.

Basic Information

Product Name	Toluene-D8
CAS No.	2037-26-5
Molecular Formula	C7D8
Molecular Weight	100.19 g/mol
Synonyms	Deuterated Toluene; Toluene-d8; Perdeuterotoluene; Methylbenzene-d8; (²H8)Toluene; Benzene, methyl-d3-d5-; Toluene (ring-d5, methyl-d3); C6D5CD3
EINECS	218-009-5

Quality Control

Our Toluene-D8 is manufactured under stringent conditions to ensure exceptional isotopic and chemical purity, meeting the exacting requirements of analytical and research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic purity (Atom % D), chemical purity by NMR and GC, and residual solvent content. We adhere to rigorous internal quality standards to guarantee batch-to-batch consistency and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept upright and sealed when not in use to prevent evaporation and potential concentration changes. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms to structure
Isotopic Purity (Atom % D)	≥ 99.5%
Chemical Purity (GC)	≥ 99.9%
Chemical Purity (¹H NMR)	≤ 0.1% protonated toluene
Water Content (KF)	≤ 0.05%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.