Description

Methadone CAS NO 297-88-1 is a synthetic opioid analgesic with a long duration of action. It is a critical active pharmaceutical ingredient (API) primarily used in the management of opioid dependence and the treatment of severe pain. This compound is essential for pharmaceutical manufacturers, research institutions, and compounding pharmacies. Its consistent quality and reliable supply are paramount for therapeutic efficacy and regulatory compliance.

Application

• Opioid Substitution Therapy (OST): As the primary active ingredient in medication-assisted treatment (MAT) programs for opioid use disorder.
• Analgesic Formulations: Used in the production of prescription pain medications for the management of severe, chronic pain.
• Pharmaceutical Research & Development: Serves as a reference standard and key intermediate in pharmacological studies and new drug development.
• Clinical Compounding: Utilized in specialized pharmacy settings to prepare customized dosage forms for specific patient needs.
• Forensic & Analytical Standards: Employed as a certified reference material in toxicology and drug testing laboratories.
• Regulatory Compliance Testing: Used by quality control laboratories to verify the identity and purity of commercial methadone products.

Basic Information

Product Name	Methadone
CAS No.	297-88-1
Molecular Formula	C21H27NO
Molecular Weight	309.45 g/mol
Synonyms	(±)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone; (±)-Methadone; DL-Methadone; Amidone; Dolophine; Heptadon; Phenadone; Adanon; Symoron; Methadose
EINECS	206-038-8

Quality Control

Our Methadone is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical use. Quality is assured through comprehensive analytical testing, including identification, assay, and impurity profiling against relevant pharmacopoeial standards such as USP and EP. A detailed Certificate of Analysis (COA) is provided with each batch, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, protect from moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.5% - 101.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.