Description

6-Ethylchenodeoxycholic-D5 Acid is a deuterated derivative of the primary bile acid chenodeoxycholic acid, specifically labeled with five deuterium atoms and featuring an ethyl substitution. This compound is of significant value as a high-purity internal standard and stable isotope-labeled tracer for advanced analytical and metabolic research. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in lipid metabolism studies, drug development, and quantitative bioanalysis using techniques like LC-MS/MS.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a critical reference compound for the accurate quantification of chenodeoxycholic acid and related bile acids in complex biological matrices.
• Metabolic Pathway Tracing: Serves as a stable isotope-labeled tracer to investigate bile acid synthesis, enterohepatic circulation, and metabolic disorders in preclinical research.
• Pharmaceutical Reference Standard: Employed in the quality control and method development for novel therapeutic agents targeting bile acid receptors or pathways.
• Biochemical Research: Facilitates studies on the role of bile acids in signaling, digestion, and their interaction with the gut microbiome.
• Diagnostic Assay Development: Utilized in the development and calibration of clinical diagnostic kits for measuring bile acid profiles.

Basic Information

Product Name	6-Ethylchenodeoxycholic-D5 Acid
CAS No.	1992000-80-2
Molecular Formula	C₂₆H₃₉D₅O₄
Molecular Weight	~ 419.65 g/mol
Synonyms	6-Ethyl-CDCA-D5; 6α-Ethyl-3α,7α-dihydroxy-5β-cholan-24-oic-2,2,3,4,4-d5 Acid; Deuterated 6-Ethylchenodeoxycholic Acid; 6-ECDCA-D5; 6-Ethyl-3α,7α-dihydroxy-5β-cholanic-24-oic-d5 Acid; (3α,5β,7α)-6-Ethyl-3,7-dihydroxycholan-24-oic-d5 Acid; 6-Ethyl-CDCA-d5; Nor-CDCA-D5 ethyl derivative
EINECS	Contact for details

Quality Control

Our 6-Ethylchenodeoxycholic-D5 Acid is manufactured under strict quality systems to ensure the high isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and deuterium enrichment. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.