Description

Doramectin Aglycone is a key chemical intermediate derived from the macrocyclic lactone class of compounds. This high-purity building block is critical for the synthesis and research of advanced antiparasitic agents. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in veterinary medicine development. Its precise structure makes it an essential precursor for creating novel therapeutic formulations.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of Doramectin and related endectocide APIs for veterinary use.
• Veterinary Drug Research: Used in R&D for developing new-generation antiparasitic treatments targeting nematodes and arthropods in livestock.
• Reference Standard: Employed as an analytical standard in quality control laboratories for HPLC or LC-MS method development and validation.
• Metabolite Studies: Facilitates research into the metabolic pathways and environmental fate of avermectin-class compounds.
• Process Chemistry: Integral to scale-up and process optimization for manufacturing complex macrocyclic lactone derivatives.
• Academic Research: Used in university and institutional labs studying the structure-activity relationships (SAR) of anthelmintic agents.

Basic Information

Product Name	Doramectin Aglycone
CAS No.	1987883-26-0
Molecular Formula	C₂₇H₄₀O₆
Molecular Weight	460.60 g/mol
Synonyms	25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl) Avermectin A1a Aglycone; (10E,14E,16E)-(1R,4S,5'S,6R,6'R,8R,12S,13S,20R,21R,24S)-6'-[(S)-sec-Butyl]-21,24-Dihydroxy-5',11,13,22-tetramethyl-2-oxo-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6-spiro-2'-(5',6'-dihydro-2'H-pyran)-12-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside Aglycone; 25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl) Abamectin Aglycone
EINECS	Contact for details

Quality Control

Our Doramectin Aglycone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.