Description

Epi-Doramectin is a high-purity, semi-synthetic macrocyclic lactone belonging to the avermectin class of compounds. This advanced intermediate is critical for the synthesis of next-generation antiparasitic agents, offering superior control over stereochemistry and impurity profiles. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in developing novel veterinary and agricultural endectocides.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel doramectin analogs and other macrocyclic lactone derivatives.
• Veterinary Drug Research: Used in the development of potent broad-spectrum antiparasitic formulations targeting nematodes and arthropods in livestock.
• Agrochemical Development: Serves as a precursor for creating advanced crop protection agents with systemic activity against insect pests.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes for the commercial production of endectocides, focusing on yield and purity.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory testing of related pharmaceutical products.
• Academic & Contract Research: Utilized in university and CRO settings for studying the structure-activity relationships (SAR) of avermectin-class molecules.

Basic Information

Product Name	Epi-Doramectin
CAS No.	1987882-62-1
Molecular Formula	C₅₀H₇₄O₁₄
Molecular Weight	899.1 g/mol
Synonyms	(4''R)-4''-Deoxy-4''-epi-doramectin; 25-Cyclohexyl-4''-epi-5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxy)-avermectin A1a; 4''-Epi-doramectin; Epi-Doramectin B1; Doramectin Epimer; (10E,14E,16E)-(1R,4S,5'S,6R,6'R,8R,12S,13S,20R,21R,24S)-6'-[(S)-sec-Butyl]-21,24-dihydroxy-5',11,13,22-tetramethyl-2-oxo-3,7,19-trioxatetracyclo[15.6.1.1⁴,⁸.0²⁰,²⁴]pentacosa-10,14,16,22-tetraene-6-spiro-2'-(5',6'-dihydro-2'H-pyran)-12-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside
EINECS	Contact for details

Quality Control

Our Epi-Doramectin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets exacting standards for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, potency, and impurity limits.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.