Description

(+)-Tetrabenazine D6 CAS NO 1977511-05-9 is a deuterated isotopologue of the vesicular monoamine transporter 2 (VMAT2) inhibitor, Tetrabenazine, where six hydrogen atoms are replaced by the stable isotope deuterium. This high-purity compound is specifically engineered for use as an internal standard in quantitative analytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers focused on central nervous system (CNS) drug discovery and bioanalytical method validation.

Application

• Primary use as a stable isotope-labeled internal standard for the quantification of Tetrabenazine and its metabolites in biological matrices via LC-MS/MS and GC-MS.
• Critical for conducting pharmacokinetic (PK) and pharmacodynamic (PD) studies in preclinical and clinical research for Huntington's disease chorea and related movement disorders.
• Enables precise drug metabolism and excretion studies, facilitating the identification and measurement of metabolic pathways.
• Supports bioanalytical method development and validation in compliance with FDA, EMA, and ICH guidelines.
• Used in doping control analysis and forensic toxicology to accurately detect and quantify Tetrabenazine.
• Essential for quality control and stability testing of pharmaceutical formulations containing Tetrabenazine.

Basic Information

Product Name	(+)-Tetrabenazine D6
CAS No.	1977511-05-9
Molecular Formula	C19H21D6NO3
Molecular Weight	323.46 g/mol
Synonyms	(+)-Tetrabenazine-d6; (3R,11bR)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one-d6; Deuterated Tetrabenazine; Tetrabenazine D6; TBZ D6; Nitoman D6; Xenazine D6; Deutetrabenazine-d6 (related compound)
EINECS	Contact for details

Quality Control

Our (+)-Tetrabenazine D6 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D6, typically >98 atom % D), chemical purity (by HPLC), and identity confirmation. Our quality commitment aligns with the standards expected for reference materials used in regulated bioanalysis.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing desiccated under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D6)	≥ 98 atom % D
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.