Description

5,7-Dibromo-6-Methyl-1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Indazole is a high-purity, advanced pharmaceutical intermediate featuring a brominated indazole core protected by a SEM (2-(trimethylsilyl)ethoxymethyl) group. This compound is specifically engineered to serve as a critical building block in modern organic synthesis, enabling the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the discovery and production of complex heterocyclic compounds for therapeutic applications.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, particularly those targeting kinase inhibition and other enzyme-related pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• Organic Synthesis Building Block: The bromine atoms and SEM-protected nitrogen offer versatile sites for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and deprotection sequences.
• Agrochemical Development: Potential application as an intermediate in the synthesis of new crop protection agents and herbicides due to its bioactive indazole scaffold.
• Material Science Research: Can be investigated as a monomer or functional additive for creating specialized polymers with unique electronic or photophysical properties.

Basic Information

Product Name	5,7-Dibromo-6-Methyl-1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Indazole
CAS No.	1973503-49-9
Molecular Formula	C15H22Br2N2OSi
Molecular Weight	434.25 g/mol
Synonyms	5,7-Dibromo-6-methyl-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-indazole; 1H-Indazole, 5,7-dibromo-6-methyl-1-[[2-(trimethylsilyl)ethoxy]methyl]-; 5,7-Dibromo-6-methyl-1-SEM-indazole; SEM-Protected 5,7-Dibromo-6-methylindazole; 1-((2-(Trimethylsilyl)ethoxy)methyl)-5,7-dibromo-6-methyl-1H-indazole
EINECS	Contact for details

Quality Control

Our 5,7-Dibromo-6-Methyl-1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should be conducted under appropriate conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.