Description

(S)-Isoindoline-1-Carboxylic Acid Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant importance in modern synthetic chemistry. Its value lies in its enantiomerically pure isoindoline scaffold, which is a privileged structure found in numerous bioactive molecules and active pharmaceutical ingredients (APIs). This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries engaged in the development of novel therapeutics, including central nervous system (CNS) agents and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of enantiomerically pure drug candidates and APIs.
• Asymmetric Synthesis: Serves as a versatile building block for constructing complex molecules with defined stereochemistry.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies for new therapeutic targets.
• Peptidomimetics: Incorporation into peptide analogs to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Foundation for creating chiral ligands and organocatalysts used in asymmetric transformations.
• Agrochemical Synthesis: Intermediate in the production of chiral pesticides and herbicides.

Basic Information

Product Name	(S)-Isoindoline-1-Carboxylic Acid Hydrochloride
CAS No.	1965314-73-1
Molecular Formula	C9H10ClNO2
Molecular Weight	199.63 g/mol
Synonyms	(S)-1,3-Dihydro-2H-isoindole-1-carboxylic acid hydrochloride; (S)-Isoindoline-1-carboxylic acid HCl; (S)-2,3-Dihydro-1H-isoindole-1-carboxylic acid hydrochloride; (1S)-2,3-Dihydro-1H-isoindole-1-carboxylic acid hydrochloride; (S)-1-Carboxyisoindoline hydrochloride; L-Isoindoline-1-carboxylic acid hydrochloride; (S)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid hydrochloride (common misnomer); (S)-1-Aminoindane-1-carboxylic acid hydrochloride derivative
EINECS	Contact for details

Quality Control

Our (S)-Isoindoline-1-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment. We support compliance with cGMP, ICH Q7, and other relevant regulatory guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.