Description

4-Thiazolecarboxylic Acid, 2-[4-[[4-(Aminosulfonyl)-3-Fluorophenyl]Methyl]-5-(Cyclopropylmethyl)-3-[3-[2-(5-Methyl-2-Thienyl)Ethynyl]Phenyl]-1H-Pyrazol-1-Yl]- is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant interest in modern pharmaceutical research and development. This compound matters because it serves as a critical building block for the synthesis of novel antiviral agents, particularly those targeting HIV-1, offering researchers a reliable and well-characterized starting material. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of next-generation therapeutic candidates.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of non-nucleoside reverse transcriptase inhibitors (NNRTIs) for antiviral therapies.
• Antiviral Drug Research: Used in the discovery and optimization of new chemical entities targeting HIV-1 and other retroviruses.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead compound optimization in academic and industrial labs.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for active pharmaceutical ingredient (API) manufacturing.
• Biochemical Research: Used as a tool compound to study enzyme inhibition mechanisms and viral resistance pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Item	Details
Product Name	4-Thiazolecarboxylic Acid, 2-[4-[[4-(Aminosulfonyl)-3-Fluorophenyl]Methyl]-5-(Cyclopropylmethyl)-3-[3-[2-(5-Methyl-2-Thienyl)Ethynyl]Phenyl]-1H-Pyrazol-1-Yl]-
CAS No.	1964517-04-1
Molecular Formula	C31H27FN4O4S2
Molecular Weight	602.70 g/mol
Synonyms	2-(4-((4-(Aminosulfonyl)-3-fluorobenzyl)-5-(cyclopropylmethyl)-3-(3-((5-methylthiophen-2-yl)ethynyl)phenyl)-1H-pyrazol-1-yl)thiazole-4-carboxylic acid; GSK-2248761 Intermediate; NNRTI Intermediate; HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor Intermediate; 4-Thiazolecarboxylic acid derivative; ViiV Healthcare development compound intermediate; (4-Carboxy-2-thiazolyl)-[4-[[4-(aminosulfonyl)-3-fluorophenyl]methyl]-5-(cyclopropylmethyl)-3-[3-[2-(5-methyl-2-thienyl)ethynyl]phenyl]pyrazol-1-yl]methanone (tautomeric form).
EINECS	Contact for details

Quality Control

Our 4-Thiazolecarboxylic Acid intermediate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliable consistency and traceability for your research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.