Description

Tasimelteon-D5 is a deuterated isotopologue of the selective melatonin receptor agonist Tasimelteon, specifically labeled with five deuterium atoms. This stable isotope-labeled compound is essential for precise pharmacokinetic and metabolic studies, providing critical internal standards for mass spectrometry-based analytical methods. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers engaged in bioanalytical method development and drug metabolism studies for Tasimelteon.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantitative bioanalysis of Tasimelteon.
• Facilitates drug metabolism and pharmacokinetics (DMPK) studies, enabling accurate tracking of the parent drug in biological matrices.
• Critical for method development and validation in regulatory-compliant bioanalytical laboratories.
• Supports clinical trial research by ensuring the accuracy and reliability of concentration data for Tasimelteon.
• Used in metabolite identification and profiling studies to understand the drug's biotransformation pathways.
• Enables high-precision quantitative analysis in pharmaceutical quality control and forensic toxicology applications.

Basic Information

Product Name	Tasimelteon-D5
CAS No.	1962124-51-1
Molecular Formula	C16H15D5N2O2
Molecular Weight	~ 285.38 g/mol
Synonyms	(1R,2R)-N-[(2-(2,3-Dihydro-1-benzofuran-4-yl)cyclopropyl]methyl]propanamide-d5; (1R-trans)-N-[[2-(2,3-Dihydrobenzofuran-4-yl)cyclopropyl]methyl]propanamide-d5; VEC-162-d5; Hetlioz-d5; Tasimelteon (pentadeuterated); Tasimelteon-d5 Internal Standard
EINECS	Contact for details

Quality Control

Our Tasimelteon-D5 is manufactured under strict quality systems to ensure high chemical and isotopic purity, meeting the exacting standards required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic enrichment (by MS), and residual solvents. We support compliance with ICH Q2(R1) and FDA guidelines for bioanalytical method validation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (HPLC)	≥ 95.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.