Description

7-Bromo-6-Methyl-1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Indazole is a high-purity, advanced pharmaceutical intermediate featuring a brominated indazole core protected by a SEM (2-(trimethylsilyl)ethoxymethyl) group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and biotechnology industries for the development of new drug candidates, particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to develop new therapeutic agents.
• Protecting Group Chemistry: The SEM-protected indazole serves as a versatile intermediate where the protecting group can be selectively removed under mild conditions to enable further functionalization.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery programs.
• Process Development: Serves as a standardized starting material for scaling up synthetic routes from laboratory to pilot plant scale.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical market.

Basic Information

Product Name	7-Bromo-6-Methyl-1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Indazole
CAS No.	1956386-57-4
Molecular Formula	C14H21BrN2OSi
Molecular Weight	341.32 g/mol
Synonyms	7-Bromo-6-methyl-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-indazole; 1H-Indazole, 7-bromo-6-methyl-1-[[2-(trimethylsilyl)ethoxy]methyl]-; 7-Bromo-6-methyl-1-SEM-indazole; SEM-Protected 7-Bromo-6-methylindazole; 1-((2-(Trimethylsilyl)ethoxy)methyl)-7-bromo-6-methyl-1H-indazole; 1956386-57-4; 7-Br-6-Me-1-SEM-indazole
EINECS	Contact for details

Quality Control

Our 7-Bromo-6-Methyl-1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply of this high-value intermediate for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.