Description

tert-Butyl 1-Oxo-1,2,3,4-Tetrahydroisoquinoline-4-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), enabling the development of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development for central nervous system (CNS) and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Drug Discovery Research: Used in medicinal chemistry for the design and construction of novel heterocyclic compounds with potential biological activity.
• Process Chemistry Development: Serves as a standard or starting material for optimizing scalable synthetic routes in pilot plants and commercial manufacturing.
• Chemical Reference Standard: Employed as a high-purity analytical standard for method development, validation, and quality control in pharmaceutical analysis.
• Academic & Industrial R&D: Utilized in research laboratories for studying reaction mechanisms and developing new synthetic methodologies.

Basic Information

Product Name	tert-Butyl 1-Oxo-1,2,3,4-Tetrahydroisoquinoline-4-Carboxylate
CAS No.	1956340-95-6
Molecular Formula	C15H17NO3
Molecular Weight	259.30 g/mol
Synonyms	4-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-1-one; 1,2,3,4-Tetrahydro-1-oxoisoquinoline-4-carboxylic acid tert-butyl ester; tert-Butyl 1-oxo-3,4-dihydroisoquinoline-4-carboxylate; 4-Boc-1,2,3,4-tetrahydroisoquinolin-1-one; 1-Oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid tert-butyl ester; Boc-THIQ-1-one-4-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-Oxo-1,2,3,4-Tetrahydroisoquinoline-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to protect the product from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.