Description

3-(Tetrahydro-2H-Pyran-4-Yl)Indolin-2-One is a high-purity pharmaceutical intermediate and organic building block featuring a fused indolinone and tetrahydropyran structure. This compound is of significant value in medicinal chemistry for its role as a versatile scaffold in the synthesis of novel bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in drug discovery and development, particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a core scaffold for constructing compound libraries for high-throughput screening (HTS) against various biological targets.
• Organic Synthesis Building Block: Used in the construction of more complex heterocyclic compounds due to its reactive ketone and aromatic systems.
• CNS Drug Development: Explored in the research of potential therapeutics for neurological disorders, given the pharmacophore's relevance to blood-brain barrier penetration.
• Kinase Inhibitor Synthesis: Employed in the development of novel kinase inhibitors for oncology and inflammatory disease research.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development.

Basic Information

Product Name	3-(Tetrahydro-2H-Pyran-4-Yl)Indolin-2-One
CAS No.	1956322-70-5
Molecular Formula	C₁₃H₁₅NO₂
Molecular Weight	217.26 g/mol
Synonyms	3-(Oxan-4-yl)-2,3-dihydro-1H-indol-2-one; 3-(Tetrahydropyran-4-yl)indolin-2-one; 2-Oxo-3-(tetrahydro-2H-pyran-4-yl)indoline; 3-(Tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-indol-2-one; 2-Indolinone, 3-(tetrahydro-2H-pyran-4-yl)-; 1956322-70-5; 3-(THP-4-yl)indolin-2-one
EINECS	Contact for details

Quality Control

Our 3-(Tetrahydro-2H-Pyran-4-Yl)Indolin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.