Description

tert-Butyl 7-Bromo-1-oxo-1,2-dihydroisoquinoline-4-carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its brominated isoquinoline core structure. This compound is of significant value for its role as a versatile building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Serves as a core structural component in the design and synthesis of potential kinase inhibitors for oncology and inflammatory diseases.
• Chemical Synthesis Building Block: Employed in organic synthesis to introduce the functionalized isoquinoline moiety into more complex molecular architectures.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for exploratory research in heterocyclic chemistry and bioorganic synthesis.

Basic Information

Product Name	tert-Butyl 7-Bromo-1-oxo-1,2-dihydroisoquinoline-4-carboxylate
CAS No.	1956317-87-5
Molecular Formula	C₁₄H₁₄BrNO₃
Molecular Weight	324.17 g/mol
Synonyms	7-Bromo-1,2-dihydro-1-oxo-4-isoquinolinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 7-bromo-1-oxo-1,2-dihydro-4-isoquinolinecarboxylate; 4-(tert-Butoxycarbonyl)-7-bromo-1,2-dihydroisoquinolin-1-one; 7-Bromo-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid tert-butyl ester; 1956317-87-5; 7-Bromo-1-oxo-1,2-dihydro-4-isoquinolinecarboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Bromo-1-oxo-1,2-dihydroisoquinoline-4-carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.