Description

4-Iodo-5-Methyl-1H-Indazole is a high-value halogenated indazole derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in providing a versatile, functionalized scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require precise building blocks for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small molecule therapeutics, particularly kinase inhibitors and other biologically active compounds.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization due to its modifiable iodine and methyl substituents.
• Agrochemical Development: Serves as a building block for creating novel active ingredients in crop protection products.
• Chemical Biology Probes: Utilized in the development of molecular probes and labeled compounds for biochemical and cellular studies.
• Material Science: Potential intermediate for the synthesis of specialized organic electronic materials and ligands for catalysis.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce complex aryl/alkynyl groups.

Basic Information

Product Name	4-Iodo-5-Methyl-1H-Indazole
CAS No.	1956309-36-6
Molecular Formula	C8H7IN2
Molecular Weight	258.06 g/mol
Synonyms	5-Methyl-4-iodo-1H-indazole; 4-Iodo-5-methylindazole; 1H-Indazole, 4-iodo-5-methyl-; 5-Methyl-4-iodoindazole; 1956309-36-6; 4-Iodo-5-methyl-1H-indazole; 4-Iodo-5-methylindazol
EINECS	Contact for details

Quality Control

Our 4-Iodo-5-Methyl-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications. Our quality commitment supports applications requiring high-purity building blocks for regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.